Lala Anthony and Carmelo Anthony are separated, and it looks like their marriage may be over for good.

Last week, pictures of Carmelo on a yacht with a scantily clad woman went viral. A few days later, People magazine reported that Lala is taking legal steps towards possibly ending their marriage.

Well yesterday Lala hosted a party in New Orleans for Essence Festival, and she let Carmelo have it. She said to the crowd, "To all my ladies who don't give a f**k about a n**ga, make some noise." Then she added, "I really don't though."

Here's the video:

NBA star Carmelo, 35, and Lala, 36, separated more than two years ago, in April 2017, after almost seven years of marriage.

At the time, the split was believed to be amicable, but “a long time coming," for the pair, who have a 12-year-old son, Kiyan.

La La Anthony has revealed that she is exploring “her legal options” as it pertains to her marriage to NBA star Carmelo Anthony.

Lala's rep released a statement to the media this week saying:

“As La La and Carmelo have been living apart for quite some time, La La is proceeding with legal discussions as the next step in their relationship. They will remain loving and committed parents to their son.”

The couple has been co-parenting their son Kiyan during this difficult period.

The couple has been married since 2010, but they hit a rocky patch in 2017 when rumors of Carmelo’s infidelity hit the news. By 2018, the couple appeared to be trying to patch things up again.

This past February, La La shared a sweet message with a not-so-subtle warning to her hubby in her Valentine’s Day message.